The NFL season is already serving up some major surprises that could completely reshape your fantasy football lineup. Star players are already dealing with unexpected setbacks that are forcing coaches to get creative with their game plans.
These developments are creating ripple effects throughout entire offensive schemes, opening up opportunities for lesser-known players to step into prominent roles. Smart fantasy managers need to stay ahead of these shifts to capitalize on the emerging waiver wire gems.
George Kittle Injury Update
The San Francisco 49ers officially placed tight end George Kittle on injured reserve because of his hamstring injury, guaranteeing that he will miss at least the next four games.
49ers placing TE George Kittle (hamstring) on IR. (via @tompelissero) pic.twitter.com/hIAhkjTSIk
— NFL (@NFL) September 9, 2025
San Francisco doesn’t have another tight end who can come close to Kittle’s production, so they will need players like WRs Ricky Pearsall and Jauan Jennings to step up in his absence. Expect both receivers, plus running back Christian McCaffrey, to see even more volume in the short term.
— PFSN Fantasy Football Analyst Dan Fornek
Kittle Fantasy Outlook
Kittle was doing “Kittle things” until he decided to do less fun “Kittle things” in the Week 1 win over the Seahawks.
Early on, he caught all four of his targets and scored on an extension play to the pylon, where he flexed his athleticism and awareness. When he’s going, he’s as good as it gets at the position. The problem is that we almost always have to navigate injuries, which is already the case in 2025.
READ MORE: Soppe’s Week 2 Fantasy Football Start ‘Em Sit ‘Em: Analysis for Every Player in Every Game
Kittle has played the full slate of games just once in his eight-year career and is now nursing a hamstring injury. I’m making other plans for Week 2 at the very least, not on waivers, but from what’s left on the wire after that.
What causes Kittle to miss time is the same mindset that makes him an elite option when active. Still, as of Thursday, with his move to the Injured Reserve, it doesn’t seem like Kittle will be suiting up on Sunday.
— PFSN Fantasy Football Analyst Kyle Soppe